GFPT1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
GFPT1
Synonyms
GFAT GFPT
Protein Name
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
UniProt ID
Q06210-2 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000349860
NCBI Gene ID
2673
Molecular Weight
78806
Protein Length
699
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2v4m)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.6.1.16; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Localization
Function
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
Gene Ontology
GO:0005829; GO:0070062; GO:0097367; GO:0004360; GO:0032922; GO:0006112; GO:0006002; GO:0006541; GO:0036498; GO:0006487; GO:0006048; GO:0006047