STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Cell membrane,Nucleus,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome;

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.

GO:1990590; GO:1990589; GO:0005813; GO:1990617; GO:0005737; GO:0032590; GO:1990037; GO:0043005; GO:0034399; GO:0005634; GO:0032991; GO:0090575; GO:0005667; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0043522; GO:0008022; GO:0046982; GO:0019901; GO:0000980; GO:0000978; GO:0000977; GO:0001085; GO:0043565; GO:0008134; GO:0044212; GO:0006874; GO:0034198; GO:1903351; GO:0042149; GO:0090650; GO:0032922; GO:0007623; GO:0007214; GO:0006094; GO:0070059; GO:0042789; GO:0120163; GO:1903204; GO:0043267; GO:0030182; GO:0036499; GO:0070169; GO:0010628; GO:0043525; GO:2000120; GO:0045943; GO:0045944; GO:1990440; GO:0036091; GO:0045893; GO:1905461; GO:0010575; GO:0006357; GO:0006355; GO:0034976; GO:1990737; GO:0009636