BCL2L1 | Bcl-2-like protein 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
BCL2L1
Synonyms
BCL2L BCLX
Protein Name
Bcl-2-like protein 1
UniProt ID
Q07817 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000302564
NCBI Gene ID
598
Molecular Weight
26049
Protein Length
233
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1bxl)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Isoform Bcl-X(L): Mitochondrion inner membrane,Mitochondrion outer membrane,Mitochondrion matrix,Cytoplasmic vesicle,Secretory vesicle,Synaptic vesicle membrane,Cytoplasm,Cytosol,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Nucleus membrane;
Function
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).Isoform Bcl-X(S) promotes apoptosis.
Gene Ontology
GO:0097136; GO:0030054; GO:0005813; GO:0005737; GO:0005829; GO:0005783; GO:0016021; GO:0005743; GO:0005759; GO:0005741; GO:0005739; GO:0031965; GO:0030672; GO:0051434; GO:0042802; GO:0046982; GO:0042803; GO:0019901; GO:0008637; GO:0071839; GO:0008283; GO:0060154; GO:0071312; GO:0071230; GO:0071480; GO:0019221; GO:0006897; GO:0097192; GO:0009566; GO:0007281; GO:0097284; GO:0001701; GO:0008630; GO:0008584; GO:0070584; GO:0007093; GO:2000811; GO:0043066; GO:0010507; GO:1902236; GO:1900118; GO:2001240; GO:1902042; GO:2001243; GO:1902230; GO:0043524; GO:1903077; GO:0090201; GO:0051402; GO:0001541; GO:0008284; GO:2001244; GO:0032465; GO:0040008; GO:0046902; GO:0051881; GO:0001836; GO:0046898; GO:0034097; GO:0007283; GO:0019050
 
Gene Ontology