CaMKinet | Result

Gene

SOS1

Synonyms

Protein Name

Son of sevenless homolog 1

UniProt ID

Q07889 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000384675

NCBI Gene ID

6654

Molecular Weight

152464

Protein Length

1333

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1awe)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Function

Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).

Gene Ontology

GO:0005737; GO:0005829; GO:0043025; GO:0000786; GO:0005886; GO:0014069; GO:0003677; GO:0005096; GO:0005085; GO:0046982; GO:0005088; GO:0005089; GO:0017124; GO:0007411; GO:0001782; GO:0048514; GO:0003209; GO:0019221; GO:0007173; GO:0038128; GO:0061029; GO:0038095; GO:0007186; GO:0001942; GO:0061384; GO:0008286; GO:0050900; GO:0000165; GO:1904693; GO:0035264; GO:0048011; GO:0003344; GO:0043065; GO:0045742; GO:0051057; GO:0007265; GO:2000973; GO:0035023; GO:0051056; GO:0033081; GO:0042129; GO:0060021; GO:0007165; GO:0007296