Protein Name
Microphthalmia-associated transcription factor
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
58605
Protein Length
526
Protein Domain
3D Structure
(PDB ID : 4ath)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) (PubMed:23207919). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Gene Ontology
GO:0005634; GO:0032991; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0070888; GO:0046983; GO:0000978; GO:0043565; GO:0046849; GO:0043010; GO:0044336; GO:0030154; GO:0045165; GO:0030318; GO:0043066; GO:0030336; GO:0000122; GO:0030316; GO:0043473; GO:2000144; GO:0010628; GO:0045944; GO:0045893; GO:0065003; GO:0042127; GO:0010468; GO:0045670; GO:2001141; GO:0006357; GO:0006355; GO:0006351; GO:0016055