Localization
Membrane,Basolateral cell membrane,Endoplasmic reticulum membrane,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell junction,Synapse,Cell membrane,Sarcolemma,Apical cell membrane,Cell junction,Cytoplasm;
Function
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
Gene Ontology
GO:0016324; GO:0005604; GO:0016323; GO:0005923; GO:0030054; GO:0031253; GO:0005911; GO:0005737; GO:0009898; GO:0005829; GO:0005783; GO:0005789; GO:0070062; GO:0098978; GO:0005794; GO:0001772; GO:0014704; GO:0043219; GO:0016328; GO:0045121; GO:0005874; GO:0097025; GO:0035748; GO:0031594; GO:0043005; GO:0033268; GO:0005634; GO:0048471; GO:0005886; GO:0098839; GO:0042383; GO:0045296; GO:0008092; GO:0004385; GO:0044325; GO:0035255; GO:0097016; GO:0031434; GO:0019902; GO:0004721; GO:0015459; GO:0008022; GO:0019901; GO:0032947; GO:0005088; GO:0098919; GO:0007015; GO:0032147; GO:0042982; GO:0030953; GO:0070830; GO:0001658; GO:0098609; GO:0034629; GO:0007268; GO:0030866; GO:0043622; GO:0048704; GO:0001935; GO:0051660; GO:0007163; GO:0045197; GO:0060022; GO:0001771; GO:0002088; GO:0000165; GO:0031579; GO:0007093; GO:0050680; GO:0070373; GO:0045930; GO:1903753; GO:0051898; GO:0042130; GO:0000122; GO:0099645; GO:0030432; GO:0030838; GO:0008284; GO:0043268; GO:1903078; GO:0072659; GO:0043113; GO:0097120; GO:0008360; GO:0042391; GO:0031641; GO:1903764; GO:1903286; GO:1902305; GO:0098911; GO:1903760; GO:0048608; GO:0048745; GO:0042110; GO:0002369; GO:0016032