ACACA | Acetyl-CoA carboxylase 1
 
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Sequence Viewer
Gene
ACACA
Synonyms
ACAC ACC1 ACCA
Protein Name
Acetyl-CoA carboxylase 1
UniProt ID
Q13085-4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000479901
NCBI Gene ID
31
Molecular Weight
265554
Protein Length
2346
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2yl2)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
6.4.1.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphateATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
Localization
Cytoplasm;
Function
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Ontology
GO:0015629; GO:0005829; GO:0001650; GO:0003989; GO:0005524; GO:0004075; GO:0042802; GO:0046872; GO:0006084; GO:0006853; GO:0071380; GO:0006633; GO:0046949; GO:0055088; GO:2001295; GO:0031325; GO:0051289; GO:0019538; GO:0045540; GO:0001894
 
Gene Ontology