CaMKinet | Result

Gene

GRM1

Synonyms

GPRC1A MGLUR1

Protein Name

Metabotropic glutamate receptor 1

UniProt ID

Q13255 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000282753

NCBI Gene ID

2911

Molecular Weight

132357

Protein Length

1194

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3ks9)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell membrane;

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Gene Ontology

GO:0030425; GO:0038037; GO:0038038; GO:0098978; GO:0005887; GO:0005634; GO:0005886; GO:0098839; GO:0098685; GO:0098872; GO:0004930; GO:0099530; GO:0008066; GO:0042802; GO:0099583; GO:0000187; GO:0000186; GO:0071257; GO:0007268; GO:0007216; GO:0007186; GO:0007626; GO:0051482; GO:0051930; GO:0051966; GO:0019233