CaMKinet | Result

Gene

MAD2L1

Synonyms

MAD2

Protein Name

Mitotic spindle assembly checkpoint protein MAD2A

UniProt ID

Q13257 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000296509

NCBI Gene ID

4085

Molecular Weight

23510

Protein Length

205

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1duj)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Chromosome,Centromere,Kinetochore,Cytoplasm,Cytoplasm,Cytoskeleton,Spindle pole;

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

Gene Ontology

GO:0005694; GO:0000777; GO:0005829; GO:0000776; GO:0072686; GO:0044615; GO:0005654; GO:0005634; GO:0048471; GO:0000922; GO:0042802; GO:0008022; GO:0042803; GO:0031145; GO:0051301; GO:0007093; GO:0000070; GO:0007094; GO:0043066; GO:0045930; GO:0042177; GO:1904667; GO:0090267; GO:1901990