Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
Gene Ontology
GO:0005829; GO:0005730; GO:0005654; GO:0005634; GO:0019005; GO:0042802; GO:0061630; GO:0004842; GO:0008283; GO:0071460; GO:0051607; GO:0000082; GO:0000086; GO:0045087; GO:0033148; GO:1902916; GO:0048661; GO:0043687; GO:0043161; GO:0016579; GO:0070936; GO:0000209; GO:0042981; GO:0051726; GO:0031146; GO:0016032