PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PPP2R5C
Synonyms
KIAA0044
Protein Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
UniProt ID
Q13362 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000329009
NCBI Gene ID
5527
Molecular Weight
61061
Protein Length
524
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2iae)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Chromosome,Centromere;
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Gene Ontology
GO:0000775; GO:0005829; GO:0005794; GO:0005654; GO:0005634; GO:0000159; GO:0072542; GO:0019888; GO:0006977; GO:0042771; GO:0008285; GO:0043161; GO:0006470; GO:0014066; GO:0031952; GO:0007165