TNK1 | Non-receptor tyrosine-protein kinase TNK1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
TNK1
Synonyms
-
Protein Name
Non-receptor tyrosine-protein kinase TNK1
UniProt ID
Q13470 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000458834
NCBI Gene ID
8711
Molecular Weight
72468
Protein Length
666
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.10.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Localization
Cytoplasm,Membrane;
Function
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Gene Ontology
GO:0005737; GO:0005829; GO:0016020; GO:0005524; GO:0004715; GO:0004713; GO:0030154; GO:0030308; GO:0046580; GO:0038083; GO:0046777; GO:0006468; GO:0042127
 
Gene Ontology