Protein Name
Sequestosome-1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
47687
Protein Length
440
Protein Domain
3D Structure
(PDB ID : 1q02)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytosol,Late endosome,Lysosome,Cytoplasmic vesicle,Autophagosome,Nucleus,Endoplasmic reticulum,Nucleus,PML body,Cytoplasm,Myofibril,Sarcomere;
Function
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102).
Gene Ontology
GO:0016235; GO:0044753; GO:0044754; GO:0005776; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016234; GO:0043231; GO:0005770; GO:0097413; GO:0005739; GO:0005654; GO:0000932; GO:0000407; GO:0016605; GO:0030017; GO:0097225; GO:0019899; GO:0042802; GO:0035255; GO:0070530; GO:0042803; GO:0019901; GO:0005080; GO:0004674; GO:0030971; GO:0042169; GO:0043130; GO:0031625; GO:0008270; GO:0035973; GO:0006915; GO:0006914; GO:0000422; GO:0030154; GO:0016197; GO:0007032; GO:0002376; GO:0070498; GO:0035556; GO:0016236; GO:0007005; GO:0000423; GO:0043066; GO:0044130; GO:0000122; GO:0043065; GO:1900273; GO:1903078; GO:0001934; GO:0045944; GO:0051291; GO:0008104; GO:1905719; GO:0043122; GO:0010821; GO:0061635; GO:0046578; GO:0002931; GO:0098780; GO:0061912; GO:0006511