EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1
 
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Sequence Viewer
Gene
EIF4EBP1
Synonyms
-
Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt ID
Q13541 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000340691
NCBI Gene ID
1978
Molecular Weight
12580
Protein Length
118
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1ej4)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Gene Ontology
GO:0005737; GO:0005829; GO:0098978; GO:0005634; GO:0099524; GO:0032991; GO:0008190; GO:0051721; GO:0030371; GO:0071549; GO:0071456; GO:0000082; GO:0008286; GO:0002192; GO:0030324; GO:0031333; GO:0045947; GO:0045931; GO:1990928; GO:0045471; GO:0002931; GO:0031929
 
Gene Ontology