RIPK1 | Receptor-interacting serine/threonine-protein kinase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
RIPK1
Synonyms
RIP RIP1
Protein Name
Receptor-interacting serine/threonine-protein kinase 1
UniProt ID
Q13546 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000259808
NCBI Gene ID
8737
Molecular Weight
75931
Protein Length
671
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6c3e)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cell membrane;
Function
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512).
Gene Ontology
GO:0005829; GO:0031264; GO:0010008; GO:0045121; GO:0005739; GO:0043235; GO:0097342; GO:0005524; GO:0070513; GO:0005123; GO:0042802; GO:0004706; GO:0004672; GO:0004674; GO:0044877; GO:0031625; GO:0006919; GO:0007257; GO:1990000; GO:0006915; GO:0097190; GO:0044257; GO:0071363; GO:0070301; GO:0071356; GO:0071550; GO:0097191; GO:0007249; GO:0000165; GO:0002756; GO:0070266; GO:0097527; GO:0060044; GO:2001237; GO:2001240; GO:1902042; GO:2000134; GO:0043124; GO:0036289; GO:0043065; GO:2001238; GO:1905206; GO:0043123; GO:0032757; GO:0046330; GO:0045651; GO:0060545; GO:0010940; GO:0051092; GO:1903800; GO:0043068; GO:0001934; GO:2000379; GO:0045944; GO:0032760; GO:1903265; GO:0097300; GO:0046777; GO:0016579; GO:0051291; GO:0051260; GO:0070926; GO:1902041; GO:0010803; GO:0034612; GO:0097343; GO:1901026; GO:0070231; GO:0034138; GO:0035666; GO:0033209; GO:0016032
 
Gene Ontology