Gene
Synonyms
CAM2 CAMK2 CAMKB
Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit beta
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
72678
Protein Length
666
Protein Domain
3D Structure
(PDB ID : 3bhh)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cytoskeleton,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Sarcoplasmic reticulum membrane,Cell junction,Synapse;
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Gene Ontology
GO:0030054; GO:0005737; GO:0005829; GO:0030666; GO:0005815; GO:0043005; GO:0005654; GO:0005886; GO:0033017; GO:0045202; GO:0003779; GO:0005524; GO:0005516; GO:0004683; GO:0042802; GO:0042803; GO:0004674; GO:0005088; GO:0060333; GO:0000165; GO:0061003; GO:0010976; GO:0090129; GO:0046777; GO:0006468; GO:0051924; GO:0060998; GO:0048169; GO:2001222; GO:0014733; GO:0051823; GO:0007165