Localization
Cell projection,Cilium membrane,Endoplasmic reticulum membrane,Cell membrane,Basolateral cell membrane,Cytoplasmic vesicle membrane,Golgi apparatus;
Function
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).
Gene Ontology
GO:0045180; GO:0009925; GO:0034703; GO:0005911; GO:0036064; GO:0060170; GO:0005929; GO:0005737; GO:0030659; GO:0005783; GO:0005789; GO:0070062; GO:0005794; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072686; GO:0031514; GO:0097730; GO:0005886; GO:0002133; GO:0042805; GO:0051117; GO:0005262; GO:0005509; GO:0048763; GO:0005261; GO:0008092; GO:0043398; GO:0042802; GO:0044325; GO:0051371; GO:0015271; GO:0051219; GO:0005267; GO:0042803; GO:0005102; GO:0005245; GO:0022843; GO:0005244; GO:0005249; GO:0005248; GO:0035904; GO:0001658; GO:0070588; GO:0006816; GO:0007050; GO:0198738; GO:0071277; GO:0071320; GO:0071498; GO:0071464; GO:0071470; GO:0034614; GO:0051298; GO:0042994; GO:0050982; GO:0003127; GO:0007368; GO:0071910; GO:0001892; GO:0007507; GO:0001947; GO:0098662; GO:0001889; GO:0072177; GO:0072164; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072284; GO:0072208; GO:0008285; GO:2000134; GO:0060315; GO:0021915; GO:0060674; GO:0071158; GO:0045737; GO:0031587; GO:0045429; GO:0045944; GO:0071805; GO:0051290; GO:0051289; GO:0051262; GO:0007259; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0035725; GO:0021510; GO:0016055