SLC12A1 | Solute carrier family 12 member 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
SLC12A1
Synonyms
NKCC2
Protein Name
Solute carrier family 12 member 1
UniProt ID
Q13621 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000370381
NCBI Gene ID
6557
Molecular Weight
121450
Protein Length
1099
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Membrane;
Function
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Gene Ontology
GO:0016324; GO:0070062; GO:0016021; GO:0016020; GO:0005886; GO:0015379; GO:0015081; GO:0015378; GO:0008511; GO:0006884; GO:0055064; GO:1902476; GO:0034220; GO:0006811; GO:0055075; GO:1990573; GO:0055078; GO:0035725
 
Gene Ontology