RIN1 | Ras and Rab interactor 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
RIN1
Synonyms
-
Protein Name
Ras and Rab interactor 1
UniProt ID
Q13671 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000310406
NCBI Gene ID
9610
Molecular Weight
84099
Protein Length
783
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Membrane,Cytoplasm,Cytoskeleton;
Function
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Gene Ontology
GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0043025; GO:0005886; GO:0005096; GO:0017112; GO:0008306; GO:0006897; GO:0007613; GO:0031914; GO:0007165