Gene
Synonyms
CACH1 CACN1 CACNL1A3
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
212350
Protein Length
1873
Protein Domain
3D Structure
(PDB ID : 2vay)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Sarcolemma,T-tubule;
Function
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Gene Ontology
GO:0005737; GO:0031674; GO:1990454; GO:0005886; GO:0030315; GO:0005891; GO:0005516; GO:0008331; GO:0046872; GO:0005245; GO:0070509; GO:0006816; GO:0071313; GO:0006936; GO:0034765