Gene
Synonyms
CDC2L CDC2L5 CHED KIAA1791
Protein Name
Cyclin-dependent kinase 13
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
164923
Protein Length
1512
Protein Domain
3D Structure
(PDB ID : 5efq)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
2.7.11.22; 2.7.11.23; (
BRENDA)
Catalytic Site
Catalytic Activity
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Nucleus speckle;
Function
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Gene Ontology
GO:0005694; GO:0002945; GO:0000307; GO:0008024; GO:0005829; GO:0005576; GO:0005615; GO:1904813; GO:0005794; GO:0000790; GO:0019908; GO:0016607; GO:0005654; GO:0005634; GO:0005524; GO:0030332; GO:0004693; GO:0004672; GO:0019901; GO:0003723; GO:0008353; GO:0008134; GO:0044212; GO:0000380; GO:0030097; GO:0007275; GO:2000737; GO:0043312; GO:0070816; GO:0008284; GO:0045944; GO:0032968; GO:0006468; GO:0007088; GO:0006368; GO:0016032