TRIM29 | Tripartite motif-containing protein 29
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
TRIM29
Synonyms
ATDC
Protein Name
Tripartite motif-containing protein 29
UniProt ID
Q14134 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000343129
NCBI Gene ID
23650
Molecular Weight
65835
Protein Length
588
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2csv)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Lysosome;
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.
Gene Ontology
GO:0005913; GO:0005764; GO:0098641; GO:0003700; GO:0042802; GO:0002039; GO:0008270; GO:0045087; GO:1900181; GO:0000122; GO:0006366