CaMKinet | Result

Gene

ARHGEF7

Synonyms

COOL1 KIAA0142 P85SPR PAK3BP PIXB

Protein Name

Rho guanine nucleotide exchange factor 7

UniProt ID

Q14155 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000325994

NCBI Gene ID

8874

Molecular Weight

90012

Protein Length

803

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1by1)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell junction,Focal adhesion,Cell projection,Ruffle,Cytoplasm,Cell cortex,Cell projection,Lamellipodium;

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Gene Ontology

GO:0005938; GO:0005829; GO:0005925; GO:0030027; GO:0043005; GO:0043025; GO:0005886; GO:0032991; GO:0001726; GO:0000322; GO:0005085; GO:0019901; GO:0005089; GO:0048013; GO:0048041; GO:0007186; GO:0007030; GO:0002244; GO:0035556; GO:0030032; GO:0042059; GO:0007399; GO:0043065; GO:0010763; GO:0060124; GO:0043547; GO:2000394; GO:0032092; GO:1900026; GO:1904424; GO:0035023; GO:0051056; GO:0007165