CaMKinet | Result

Gene

TFDP1

Synonyms

DP1

Protein Name

Transcription factor Dp-1

UniProt ID

Q14186 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000364519

NCBI Gene ID

7027

Molecular Weight

45070

Protein Length

410

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2aze)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Cytoplasm;

Function

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Gene Ontology

GO:0005829; GO:0005739; GO:0005654; GO:0005634; GO:0090575; GO:0003677; GO:0003700; GO:0000981; GO:0019904; GO:0003713; GO:0008134; GO:0043276; GO:0008283; GO:0006977; GO:0008544; GO:0070345; GO:0070317; GO:1900740; GO:0045944; GO:2000278; GO:0006357; GO:0000083