BECN1 | Beclin-1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
BECN1
Synonyms
GT197
Protein Name
Beclin-1
UniProt ID
Q14457 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000355231
NCBI Gene ID
8678
Molecular Weight
51896
Protein Length
450
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2p1l)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Golgi apparatus,trans-Golgi network membrane,Endosome membrane,Endoplasmic reticulum membrane,Mitochondrion membrane,Endosome,Cytoplasmic vesicle,Autophagosome;Beclin-1-C 35 kDa: Mitochondrion,Nucleus,Cytoplasm;Beclin-1-C 37 kDa: Mitochondrion;
Function
Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
Gene Ontology
GO:0005776; GO:0005829; GO:0030425; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0019898; GO:0031966; GO:0005634; GO:0045335; GO:0000407; GO:0035032; GO:0034271; GO:0034272; GO:0005802; GO:0051020; GO:0043548; GO:0042803; GO:0019901; GO:0031625; GO:0007568; GO:0050435; GO:0006915; GO:0000045; GO:0006914; GO:0000422; GO:0051301; GO:0006968; GO:0071275; GO:0034198; GO:0071280; GO:0071364; GO:0042149; GO:0070301; GO:0006995; GO:0051607; GO:0045022; GO:0043652; GO:0045324; GO:0007040; GO:0016236; GO:0000423; GO:0007080; GO:0043066; GO:1902902; GO:0060548; GO:0008285; GO:1905672; GO:2000378; GO:0048666; GO:1902425; GO:2000786; GO:0010613; GO:0014068; GO:0016579; GO:0032258; GO:0032801; GO:0050790; GO:0032465; GO:0001666; GO:0010040; GO:0010288; GO:0098780; GO:0033197; GO:0016032
 
Gene Ontology