Protein Name
Sodium channel protein type 5 subunit alpha
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
226940
Protein Length
2016
Protein Domain
3D Structure
(PDB ID : 2kbi)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cytoplasm,Perinuclear region,Cell membrane,Sarcolemma,T-tubule;
Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138).
Gene Ontology
GO:0030424; GO:0005901; GO:0009986; GO:0005783; GO:0016021; GO:0014704; GO:0005622; GO:0016328; GO:0048471; GO:0005886; GO:0042383; GO:0030315; GO:0001518; GO:0030018; GO:0030506; GO:0005516; GO:0019899; GO:0017134; GO:0044325; GO:0050998; GO:0019904; GO:0019901; GO:0097110; GO:0031625; GO:0005244; GO:0005248; GO:0086060; GO:0086061; GO:0086006; GO:0086062; GO:0086063; GO:0086014; GO:0086016; GO:0086067; GO:0003360; GO:0086043; GO:0086002; GO:0060048; GO:0003231; GO:0071277; GO:0021549; GO:0051899; GO:0086010; GO:0098912; GO:0086045; GO:0086048; GO:0086012; GO:0086047; GO:0086046; GO:0019228; GO:0042475; GO:0045760; GO:0050679; GO:0010765; GO:0060371; GO:0060372; GO:0086004; GO:0002027; GO:0086091; GO:1902305; GO:0060373; GO:0060307; GO:0014894; GO:0086015; GO:0035725; GO:0006814; GO:0021537; GO:0086005