ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
ITPR2
Synonyms
-
Protein Name
Inositol 1,4,5-trisphosphate receptor type 2
UniProt ID
Q14571 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000242737
NCBI Gene ID
3709
Molecular Weight
308064
Protein Length
2701
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Endoplasmic reticulum membrane;
Function
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
Gene Ontology
GO:0005938; GO:0030659; GO:0005783; GO:0005789; GO:0016021; GO:0016020; GO:0005634; GO:0005886; GO:0031095; GO:0043235; GO:0016529; GO:0033017; GO:0030667; GO:0005509; GO:0015085; GO:0070679; GO:0005220; GO:0035091; GO:0097110; GO:0071320; GO:0071361; GO:0030168; GO:1903779; GO:0050796; GO:0051209; GO:0001666; GO:0007165
 
Gene Ontology