STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

-

Cytoplasm,Nucleus;

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0003677; GO:0001228; GO:0000981; GO:0001227; GO:0042802; GO:0019904; GO:0042803; GO:0000978; GO:0043565; GO:0003712; GO:0006915; GO:0006974; GO:0071360; GO:0051607; GO:0060333; GO:0031663; GO:0071888; GO:0039530; GO:0032480; GO:0050715; GO:0043123; GO:0032727; GO:0032728; GO:0045944; GO:0032481; GO:0060340; GO:0097300; GO:0050727; GO:0032479; GO:0006366; GO:0035666; GO:0045351; GO:0060337; GO:0016032