Gene
Synonyms
ESP1 KIAA0165
Protein Name
Separin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
233175
Protein Length
2120
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.
Localization
Cytoplasm,Nucleus;
Function
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Gene Ontology
GO:0005813; GO:0005737; GO:0005829; GO:0072686; GO:0005634; GO:0003824; GO:0004197; GO:0008234; GO:0006915; GO:0040001; GO:0045143; GO:0051307; GO:0000212; GO:0000281; GO:0000070; GO:0045875; GO:0045842