Protein Name
Sorting nexin-17
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
52901
Protein Length
470
Protein Domain
3D Structure
(PDB ID : 3fog)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Early endosome,Cytoplasmic vesicle membrane;
Function
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Gene Ontology
GO:0031410; GO:0030659; GO:0005829; GO:0005769; GO:0005768; GO:0010008; GO:0005794; GO:0043231; GO:0016020; GO:0032991; GO:0050750; GO:0035091; GO:0008022; GO:0005102; GO:0035904; GO:0003279; GO:0006707; GO:0060976; GO:0016197; GO:0006886; GO:0006898; GO:0030100; GO:1990126; GO:0007165