Gene
Synonyms
CDK5R NCK5A
Protein Name
Cyclin-dependent kinase 5 activator 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
34060
Protein Length
307
Protein Domain
3D Structure
(PDB ID : 1ung)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane;Cyclin-dependent kinase 5 activator 1, p25: Nucleus,Cytoplasm,Perinuclear region;
Function
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Gene Ontology
GO:0030424; GO:0043292; GO:0005737; GO:0005829; GO:0030425; GO:0043197; GO:0030426; GO:0043231; GO:0016020; GO:0031594; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0098793; GO:0016533; GO:0051015; GO:0043014; GO:0048487; GO:0045296; GO:0005509; GO:0061575; GO:0046875; GO:0035255; GO:0016301; GO:0002020; GO:0004672; GO:0019901; GO:0043539; GO:0007411; GO:0007413; GO:0007420; GO:0008283; GO:0021549; GO:0009792; GO:0048013; GO:0007213; GO:0021766; GO:0035235; GO:0021819; GO:0000226; GO:0030517; GO:0045892; GO:0007158; GO:0030182; GO:0001764; GO:0031175; GO:0018105; GO:0018107; GO:0071158; GO:0031116; GO:0043525; GO:0090314; GO:0032956; GO:0000079; GO:0061001; GO:0016241; GO:0045664; GO:0098693; GO:0048511; GO:0042501; GO:0021722