RABEP1 | Rab GTPase-binding effector protein 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
RABEP1
Synonyms
RAB5EP RABPT5 RABPT5A
Protein Name
Rab GTPase-binding effector protein 1
UniProt ID
Q15276 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000339569
NCBI Gene ID
9135
Molecular Weight
99290
Protein Length
862
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1p4u)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Early endosome,Recycling endosome,Cytoplasmic vesicle;
Function
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).
Gene Ontology
GO:0005769; GO:0031901; GO:0030139; GO:0005768; GO:0043231; GO:0032991; GO:0055037; GO:0008083; GO:0005096; GO:0019904; GO:0042803; GO:0006915; GO:0006897; GO:0006893; GO:0061025; GO:1903441; GO:0015031; GO:0016192
 
Gene Ontology