RPS6KA2 | Ribosomal protein S6 kinase alpha-2
 
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Sequence Viewer
Gene
RPS6KA2
Synonyms
MAPKAPK1C RSK3
Protein Name
Ribosomal protein S6 kinase alpha-2
UniProt ID
Q15349 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000265678
NCBI Gene ID
6196
Molecular Weight
83239
Protein Length
733
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Nucleus,Cytoplasm;
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0016301; GO:0000287; GO:0004674; GO:0004712; GO:0004711; GO:0035556; GO:0045786; GO:0008285; GO:0043065; GO:0007165
 
Gene Ontology