RHEB | GTP-binding protein Rheb
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
RHEB
Synonyms
RHEB2
Protein Name
GTP-binding protein Rheb
UniProt ID
Q15382 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262187
NCBI Gene ID
6009
Molecular Weight
20497
Protein Length
184
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1xtq)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Endomembrane system,Golgi apparatus membrane,Cytoplasm,Cytosol,Endoplasmic reticulum membrane;
Function
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Gene Ontology
GO:0005829; GO:0005789; GO:0070062; GO:0000139; GO:0005765; GO:0016020; GO:0014069; GO:0005681; GO:0019003; GO:0005525; GO:0003924; GO:0000287; GO:0019901; GO:0007050; GO:0120163; GO:0048714; GO:0032008; GO:0016241; GO:2000074; GO:0007165
 
Gene Ontology