Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Gene Ontology
GO:0000785; GO:0016592; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0032993; GO:0000151; GO:0003682; GO:0031490; GO:0030331; GO:0050693; GO:0036033; GO:0035257; GO:0016922; GO:0030374; GO:0042975; GO:0042974; GO:0000979; GO:0000978; GO:0038023; GO:0046966; GO:0030375; GO:0003713; GO:0003712; GO:0003714; GO:0008134; GO:0061630; GO:0042809; GO:0006702; GO:0001525; GO:0031100; GO:0007420; GO:0000902; GO:0071364; GO:0035729; GO:0071383; GO:0097067; GO:0035050; GO:0035162; GO:0035116; GO:0001892; GO:0048822; GO:0060750; GO:0070371; GO:0048821; GO:0045444; GO:0030518; GO:0030216; GO:0007595; GO:0002088; GO:0001889; GO:0060745; GO:0060744; GO:0035855; GO:0030224; GO:0042789; GO:0043066; GO:0010839; GO:0045665; GO:0000122; GO:0035357; GO:0045648; GO:0070318; GO:0010628; GO:2000347; GO:0060335; GO:0033148; GO:0045618; GO:0033601; GO:2000273; GO:0045944; GO:0045893; GO:0051726; GO:0019216; GO:2001141; GO:0006356; GO:0070562; GO:0003406; GO:0006590; GO:0002154; GO:0006367; GO:0003222