STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Nucleus;

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

GO:0032444; GO:0005737; GO:0005829; GO:0071144; GO:0000790; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667; GO:0033613; GO:0003682; GO:0070410; GO:0097718; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0035326; GO:0070411; GO:0046872; GO:0019902; GO:0070878; GO:0046982; GO:0042803; GO:0070412; GO:0000978; GO:0046332; GO:0048156; GO:0008134; GO:0005160; GO:0030618; GO:0034713; GO:0031625; GO:0032924; GO:0030325; GO:0009952; GO:0045165; GO:0007182; GO:0048701; GO:0048617; GO:0001706; GO:0007369; GO:0001701; GO:0030073; GO:0035556; GO:0030324; GO:0001707; GO:0008285; GO:0000122; GO:0045892; GO:0030512; GO:0038092; GO:0035265; GO:0031016; GO:0048340; GO:0060039; GO:0030513; GO:0010718; GO:1900224; GO:0045944; GO:0045893; GO:0009791; GO:0031053; GO:0016579; GO:0051098; GO:0017015; GO:0070723; GO:0009749; GO:0062009; GO:0023019; GO:0007183; GO:0060395; GO:0035019; GO:0007179; GO:0001657; GO:0042060; GO:0007352