CaMKinet | Result

Gene

NFE2L2

Synonyms

NRF2

Protein Name

Nuclear factor erythroid 2-related factor 2

UniProt ID

Q16236-2 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000380252

NCBI Gene ID

4780

Molecular Weight

67827

Protein Length

605

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2flu)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Cytosol,Nucleus;

Function

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Gene Ontology

GO:0005813; GO:0000785; GO:0005737; GO:0005829; GO:0005794; GO:0005654; GO:0005634; GO:0005886; GO:0032993; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019904; GO:0001102; GO:0000980; GO:0001221; GO:0044212; GO:0000976; GO:0046223; GO:0007568; GO:0045454; GO:1904385; GO:0071498; GO:0042149; GO:0070301; GO:0071499; GO:0034599; GO:0071356; GO:0030968; GO:0006954; GO:0010667; GO:2000352; GO:1902037; GO:1903206; GO:1902176; GO:1904753; GO:0036499; GO:0045766; GO:0030194; GO:0043536; GO:1903071; GO:0010628; GO:0046326; GO:1903788; GO:0010976; GO:2000379; GO:0045944; GO:0061419; GO:0036091; GO:0036003; GO:0045893; GO:0010499; GO:0043161; GO:0016567; GO:0045995; GO:2000121; GO:0006366; GO:0016032