Protein Name
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
45024
Protein Length
387
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).
Gene Ontology
GO:0005829; GO:0005964; GO:0005524; GO:0005516; GO:0004683; GO:0019899; GO:0004689; GO:0050321; GO:0005975; GO:0005978