Numb | Protein numb homolog
 
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Sequence Viewer
Gene
Synonyms
-
Protein Name
Protein numb homolog
UniProt ID
Q2LC84 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
70596
Protein Length
652
Protein Domain
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Catalytic Activity
-
Localization
Membrane;
Function
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage (By similarity).
Gene Ontology
GO:0045177; GO:0098978; GO:0016020; GO:0014069; GO:0030154; GO:0008283; GO:0050775; GO:0045664; GO:0099150