Crtc2 | CREB-regulated transcription coactivator 2
 
Sequence Viewer
Gene
Crtc2
Synonyms
Torc2
Protein Name
CREB-regulated transcription coactivator 2
UniProt ID
Q3U182 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000029545
NCBI Gene ID
74343
Molecular Weight
73216
Protein Length
692
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5zk1)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Nucleus;
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).
Gene Ontology
GO:0005737; GO:0005654; GO:0005634; GO:0008140; GO:0003682; GO:0006094; GO:0042593; GO:0043970; GO:0032793; GO:0045944; GO:0051289; GO:1901998