FBXO43 | F-box only protein 43
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
FBXO43
Synonyms
EMI2
Protein Name
F-box only protein 43
UniProt ID
Q4G163 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000403293
NCBI Gene ID
286151
Molecular Weight
78402
Protein Length
708
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Function
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
Gene Ontology
GO:0005634; GO:0046872; GO:0051321; GO:0045835; GO:0016567