CaMKinet | Result

Gene

PDCD4

Synonyms

H731

Protein Name

Programmed cell death protein 4

UniProt ID

Q53EL6 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000280154

NCBI Gene ID

27250

Molecular Weight

51735

Protein Length

469

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2ggf)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Cytoplasm;

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Gene Ontology

GO:0005737; GO:0005829; GO:0005634; GO:0003723; GO:0006915; GO:0030509; GO:0007569; GO:0071222; GO:0060940; GO:0035722; GO:0043066; GO:0045786; GO:1900016; GO:0043508; GO:1904761; GO:0045892; GO:1905064; GO:1904706; GO:2000353; GO:0050729; GO:1901224; GO:1905461