Function
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:12654725, PubMed:19590578). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (By similarity). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (By similarity). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (By similarity). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation (By similarity). Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (By similarity). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity).
Gene Ontology
GO:0005829; GO:0031264; GO:0045121; GO:0005739; GO:0032991; GO:0043235; GO:0097342; GO:0005524; GO:0070513; GO:0005123; GO:0042802; GO:0004706; GO:0004672; GO:0004674; GO:0044877; GO:0031625; GO:0007257; GO:1990000; GO:0006915; GO:0044257; GO:0071363; GO:0070301; GO:0071356; GO:0097191; GO:0000165; GO:0070266; GO:0097527; GO:0060044; GO:2001237; GO:2001240; GO:2000134; GO:0043124; GO:0036289; GO:0043065; GO:0010942; GO:2001238; GO:1905206; GO:0043123; GO:0032757; GO:0046330; GO:0045651; GO:0043410; GO:0060545; GO:0010940; GO:0051092; GO:0042327; GO:1903800; GO:0043068; GO:0001934; GO:0045944; GO:0032760; GO:1903265; GO:0097300; GO:0046777; GO:0051291; GO:0051260; GO:0070926; GO:2000377; GO:0034612; GO:0097343; GO:1901026; GO:0070231; GO:0016032