Protein Name
Bcl2-associated agonist of cell death
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
22080
Protein Length
204
Protein Domain
3D Structure
(PDB ID : 2bzw)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Mitochondrion outer membrane,Cytoplasm;
Function
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Gene Ontology
GO:0005737; GO:0005829; GO:0005741; GO:0005739; GO:0071889; GO:0008656; GO:0008289; GO:0005543; GO:0046982; GO:0043422; GO:0019901; GO:0030346; GO:0019903; GO:0097202; GO:0006919; GO:0046031; GO:0006915; GO:0097190; GO:0046034; GO:0008283; GO:0060154; GO:0071247; GO:0071456; GO:0071396; GO:0071260; GO:0071316; GO:0071310; GO:0021987; GO:0019221; GO:0097191; GO:0097192; GO:0008625; GO:0006007; GO:0042593; GO:0097193; GO:0008630; GO:0046931; GO:0043065; GO:0060139; GO:0045579; GO:0043280; GO:0050679; GO:0033133; GO:1904710; GO:0032024; GO:0035774; GO:1902220; GO:0010918; GO:1901216; GO:0045862; GO:0090200; GO:0045582; GO:2000078; GO:0042981; GO:0043281; GO:0046902; GO:0001836; GO:0043200; GO:0051592; GO:0032355; GO:0045471; GO:0051384; GO:0009749; GO:0042542; GO:0034201; GO:0032570; GO:0033574; GO:0007283; GO:0019050; GO:0044342