Protein Name
PRKC apoptosis WT1 regulator protein
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
35866
Protein Length
332
Protein Domain
3D Structure
(PDB ID : 5fiy)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
Gene Ontology
GO:0005884; GO:0030424; GO:0005737; GO:0043005; GO:0043025; GO:0005634; GO:0003779; GO:0005080; GO:0008157; GO:0051017; GO:0097202; GO:0006915; GO:0098703; GO:0071392; GO:0071372; GO:0071347; GO:0071306; GO:0050966; GO:0050965; GO:0090281; GO:0045760; GO:0043065; GO:0060450; GO:1903238; GO:0043525; GO:1904457; GO:2000391; GO:0032516; GO:1901082; GO:0032355; GO:0010040; GO:0032496; GO:0009611