Gene
Synonyms
Arhgap7 Rhogap Stard12
Protein Name
Rho GTPase-activating protein 7
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
123414
Protein Length
1091
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cell junction,Focal adhesion,Membrane;
Function
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity).
Gene Ontology
GO:0005737; GO:0005925; GO:0045121; GO:0005096; GO:0008289; GO:0043274; GO:0017166; GO:0007202; GO:0032869; GO:0007010; GO:0008285; GO:0035023; GO:0007165