Protein Name
Wee1-like protein kinase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
62343
Protein Length
555
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0000287; GO:0004715; GO:0004672; GO:0004713; GO:0007143; GO:0035038; GO:0007093; GO:0045736; GO:1900194; GO:0042327; GO:0080154; GO:0060631