Protein Name
CREB-binding protein
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
265424
Protein Length
2442
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity).
Gene Ontology
GO:0005737; GO:0000123; GO:0016604; GO:0005634; GO:0032991; GO:0005667; GO:0016407; GO:0033613; GO:0003682; GO:0003684; GO:0004402; GO:0043426; GO:0042975; GO:0046332; GO:0003713; GO:0008270; GO:0008283; GO:0034644; GO:0016573; GO:0060355; GO:1900087; GO:1901224; GO:0045944; GO:0045893; GO:0031648; GO:0006355; GO:0070555; GO:0048511