CRTC3 | CREB-regulated transcription coactivator 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
CRTC3
Synonyms
TORC3
Protein Name
CREB-regulated transcription coactivator 3
UniProt ID
Q6UUV7 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000268184
NCBI Gene ID
64784
Molecular Weight
66959
Protein Length
619
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Cytoplasm;
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0008140; GO:0097009; GO:0042116; GO:0043951; GO:0050995; GO:0032793; GO:0045944; GO:0051289; GO:0016032