Gene
Synonyms
AGPAT11 AYTL1
Protein Name
Lysophosphatidylcholine acyltransferase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
60208
Protein Length
544
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoAa 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
Localization
Endoplasmic reticulum membrane,Golgi apparatus membrane,Lipid droplet;
Function
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
Gene Ontology
GO:0005783; GO:0005789; GO:0000139; GO:0005795; GO:0016021; GO:0005811; GO:0003841; GO:0047184; GO:0047192; GO:0047144; GO:0005509; GO:0061024; GO:0036151; GO:0006663